This is the first study to draw on international research carried out across four EU member states to add to the neglected area of the creative economy of peripheral regions.Economies are dynamic entities and subject to constant flux. Driven by changing tastes, new ways to make and disruptive innovations, new routes of economic development present themselves at ever increasing rates. This study is concerned with the rise of the creative economy. UNCTAD has marked the emergence of the creative economy across the globe and noted its resilience in the face of recent economic turmoil. Here, the authors intend to bring the level of analysis down to the regional and firm level by uncovering the extent of the creative economy in some of Europe’s most peripheral regions. This is the first study to draw on international research carried out across four EU member states to add to the neglected area of the creative economy of peripheral regions. The work contributes to expanding theory in the areas of economic geography, business studies and regional development.